You may have noticed that Prolynx scientists value publishing their novel research in high-quality, peer-reviewed-journals. We are proud to be the sole non-academic group recognized as one of the "selected highly-prolific authors" in the past 5 years for Bioconjugate Chemistry on their Journal Stars website: http://journalstars.acs.org/biological/journal/bioconjugate-chemistry.
Henise, J. et al. In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates. International Journal of Polymer Science, Vol. 2019, Article ID 9483127. (2019)
Machinaga, N. et al. A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules. TVST, Vol. 7, No. 4, Article 21. (2018)
Hearn, B. et al. Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system. Journal of Controlled Release, 278, 74-79. (2018)
Schneider, E. et al. A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP‑1 Receptor Agonist. ACS Chemical Biology, 12, 2107-2116. (2017)
Schneider, E. et al. Approach For Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake. Bioconjugate Chemistry, 27, 2534-2539. (2016)
Henise, J. et al. Surgical Sealants with Tunable Swelling, Burst Pressures, and Biodegradation Rates. Journal of Biomedical Materials Research, B, 00B:000-000; doi: 10.1002/jbm.b.33701. (2016)
Cerchiari, A.E. et al. Probing the Luminal Microenvironment of Reconstituted Epithelial Microtissues. Scientific Reports, 6,33148; doi: 10.1038/srep33148. (2016)
Schneider, E. et al. Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugated Provide Very Long-Acting Octreotide. Bioconjugate Chemistry, 27, 1638-1644. (2016)
Schneider, E. et al. Hydrogel Drug Delivery System Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide. Bioconjugate Chemistry, 27, 1210-1215. (2016)
Reid, R. et al. Analytical and Simulation-Based Models for Drug Release and Gel-Degradation in a Tetra-PEG Hydrogel Drug-Delivery System. Macromolecules, 2015, 48, 7359-7369. (2015)
Schneider, E. et al. Half-Life Extension of the HIV-Fusion Inhibitor Peptide TRI-1144 Using a Novel Linker Technology. European Journal of Pharmaceuticals and Biopharmaceutics, 93, 254-259. (2015)
Henise, J. et al. Biodegradable Tetra-PEG Hydrogels as Carriers for a Releasable Drug Delivery System. Bioconjugate Chem, 26, 270-278. (2015)
Fontaine, S. et al. Long-Term Stabilization of Maleimide−Thiol Conjugates. Bioconjugate Chem., 26, 145-152. (2015)
Lawrence, M. et al. The Intravitreal Pharmacokinetics of Fluorophores Conjugated to PEGs by Non-Cleavable and Self-Cleaving Linkers in Non-human Primates. ARVO 2014 Annual Meeting. (2014)
Santi, D.V. et al. Macromolecular Prodrug that provides the Irinotecan Active-Metabolite SN-38 with Ultralong Half-Life, Low Cmax, and Low Glucuronide Formation. J.MedChem., 57, 2303-2314. (2014)
Schneider, E. et al. Beta-Eliminative Releasable Linkers Adapted for Bioconjugation of Macromolecules to Phenols. Bioconjugate Chem., 24, 1990-1997. (2013)
Henise, J. et al. An optimized hydrogel offers tunable half-life extension of peptides and proteins. Peptide Conference 2013.
Schneider, E.L., et al. Self-administered long-acting octreotide conjugates. Peptide Conference 2013.
Ashley, G.W. et al. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. PNAS, 110(6), 2318-2323. (2013)
Schneider, E.L. et al. Predictable half-life extension demonstrated through peptide TRI-1144. Peptide Conference 2012.
Henise, J. et al. A biodegradable hydrogel drug delivery system for tunable half-life extension. Peptide Conference 2012.
Santi, D.V. et al. Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates. PNAS, 109(16), 6211-6216. (2011)
Schneider, E. et al. Predictable and tunable drug release from macro-molecular conjugates. Peptide Conference 2011.
We have eight issued US Patents and fourteen follow on patent applications pending in the US and internationally. These claim advances in linker technology, the use of cleavable linkers in soluble circulating and solid supports, including hydrogels. Certain applications have claims directed towards specific therapeutic applications and compositions of matter.
Patent No. 10,086,049 | Conjugates of somatostatin analogs | October 2, 2018
Patent No. 10,016,411 | Slow-release conjugates of SN-38 | July 10, 2018
Patent No. 9,649,385 | Claims on biodegradable hydrogels | May 16, 2017
Patent No. 9,387,254 | Claims on linkers | July 12, 2016
Patent No. 8,946,405 | Claims on linkers on solid supports | February 3, 2015
Patent No. 8,754,190 | Claims on adapted linkers for non-amines | June 17, 2014
Patent No. 8,703,907 | Claims on dendrimers with releasable linkers | April 22, 2014
Patent No. 8,680,315 | Claims on linkers, soluble conjugates | March 25, 2014